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Luisa Mestroni, MD

Professor, Medicine-Cardiology
Mestroni
Clinic Phone: 720-848-5300

Specialties: Advanced Heart Failure and Transplant Cardiology, Cardiovascular Disease, ECFMG/USMLE

Location: Aurora - University of Colorado Hospital (UCH)

Conditions & Treatments: Genetic Conditions and Testing, Heart and Circulation, Heart and Circulation - Cardiomyopathy, Heart and Circulation - Heart Diseases, Heart and Circulation - Heart Failure

 
General Information
Gender: Female
Languages: English, Italian
Clinical Interest for Patients: My many clinical interests include general Clinical Cardiology, Advanced Heart Failure and Transplant, Genetics of Cardiovascular Disorders, Cardiomyopathies (dilated, hypertrophic, arrhythmogenic, left ventricular non-compaction, rare cardiomyopathies)
Care Philosophy: I strive to provide the best care for my patients. I believe in treating the person as a whole, taking every aspect of a patient’s body and health into consideration during diagnosis and treatment.
Personal Interests: In my spare time, I enjoy skiing, hiking, reading and spending time with my family.
Volunteer Activities: I volunteer as physician in sports activities of high school students.
Education and Training
Medical Schools
MD, University of Trieste, School of Medicine, Italy (1979)

Undergraduate Schools
BS, University of Trieste, School of Medicine, Italy (1979)

Fellowships
University of Trieste, School of Medicine, Italy, Internal Medicine - Interventional Cardiology (1989)

Specialty Information
Specialties
Internal Medicine - Advanced Heart Failure and Transplant Cardiology
Internal Medicine - Cardiovascular Disease, International Certification (1989)
ECFMG/USMLE, License (2000)

Conditions & Treatments
Genetic Conditions and Testing
Heart and Circulation
Heart and Circulation - Cardiomyopathy
Heart and Circulation - Heart Diseases
Heart and Circulation - Heart Failure
Practice Locations
Hospital Affiliation
University of Colorado Hospital

Clinical Location
University of Colorado Hospital (UCH)
12605 E. 16th Ave.
Aurora, CO 80045
(720) 848-0000 
Website

Job Titles
Academic - Professor

Department, Section / Division
Medicine, Medicine-Cardiology

Center Affiliations
Human Medical Genetics Program

Professional Memberships
American Heart Association - Fellow
American College of Cardiology - Fellow
European Society of cardiology - Fellow
American College of Physician - Fellow
American Society of Human Genetics - Member
European Society of Human Genetics - Member
Research & Grants
Website
http://www.ncbi.nlm.nih.gov/pubmed?term="Mestroni L"[Author]

Research Interests
My research is dedicated to the study of genetics of heart muscle diseases, called cardiomyopathies. Since 1991, we have collected clinical information and DNA of over 1700 subjects from families with cardiomyopathies, initially in Italy and subsequently in the USA. Data and materials are collected in the International Familial Registry which has been supported by various grants of the NIH, AHA, UN, MDA. Through our researches on the molecular genetics of cardiomyopathies and analysis on genotype-phenotype correlations, several genes and pathways causing heart disease have been investigated in my laboratory, from cytoskeletal and sarcomeric genes, to ion channels. We are interested in the genes causing dilated cardiomyopathy, arrhythmogenic right ventricular dysplasia, left ventricular noncompaction and hypertrophic cardiomyopathy. Our ongoing research has shown that specific genes may have a different prognosis and may suggest different management strategies. Functional studies of mutant cardiomyopathy genes are also performed to evaluate the consequences of the defective proteins on cellular models. We are currently exploring applications of nanotechnology and bioengineering to the study of heart function and cardiomyopathies.
Teaching
Professor of Medicine (1998)
School of Medicine
Medicine
Heart Failure, Cardiomyopathies, Genetic of Heart Disease

Information for Referring Providers
Clinical Interests for Referring Providers: My many clinical interests include Clinical Cardiology, Advanced Heart Failure and Transplant, Genetics of Cardiovascular Disorders, Cardiomyopathies (DCM, HCM, ARVC, LVNC, rare cardiomyopathies)

Research Interest for Referring Providers: My research is dedicated to the study of genetics of heart muscle diseases, called cardiomyopathies. Since 1991, we have collected clinical information and DNA of over 1700 subjects from families with cardiomyopathies, initially in Italy and subsequently in the USA. Data and materials are collected in the International Familial Registry which has been supported by various grants of the NIH, AHA, UN, MDA. Through our researches on the molecular genetics of cardiomyopathies and analysis on genotype-phenotype correlations, several genes and pathways causing heart disease have been investigated in my laboratory, from cytoskeletal and sarcomeric genes, to ion channels. We are interested in the genes causing dilated cardiomyopathy, arrhythmogenic right ventricular dysplasia, left ventricular noncompaction and hypertrophic cardiomyopaty. Among the most important accomplishments are the discovery of dilated cardiomyopathy genes, such as lamin A/C (LMNA) associated with variable muscular involvement, LAP2, SCN5A and MYH6, and the recent discovery of the titin gene (TTN), the largest gene of the human genome, as a cause of arrhythmogenic right ventricular cardiomyopathy. We are also interested in genotype-phenotype association studies, which are critical to transfer bench-to-bedside knowledge. Our ongoing research has shown that specific genes may have a different prognosis and may suggest different management strategies. Functional studies of mutant cardiomyopathy genes are also performed to evaluate the consequences of the defective proteins on cellular models. We are currently exploring applications of nanotechnology and bioengineering to the study of heart function and cardiomyopathies.

Hospital Affiliation
University of Colorado Hospital

Clinical Location: Aurora - University of Colorado Hospital (UCH)

Clinic Phone: 720-848-5300
CV: CURRICULUM VITAE.March 2012.pdf
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