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V. Michael Holers, MD

Professor, Medicine-Rheumatology
Holers
Clinic Phone: 720-848-1940

Specialties: Rheumatology, Internal Medicine

Location: Aurora - Barbara Davis Center for Childhood Diabetes - Specialty Clinic

General Information
Gender: Male
Language: English
Education and Training
Medical Schools
MD, Washington University in St. Louis School of Medicine (1978)

Internships
Washington University/Barnes-Jewish Hospital/St. Louis Children’s Hospital (1979)

Residency Program
Washington University/Barnes-Jewish Hospital/St. Louis Children’s Hospital, Internal Medicine (1981)

Fellowships
University of Colorado, Internal Medicine - Rheumatology (1983)
Washington University/Barnes-Jewish Hospital/St. Louis Children’s Hospital, Internal Medicine - Rheumatology (1985)

Specialty Information
Specialties
Internal Medicine - Rheumatology, Board Certification
Internal Medicine, Board Certification

Practice Locations
Hospital Affiliation
University of Colorado Hospital

Clinical Location
Barbara Davis Center for Childhood Diabetes - Specialty Clinic
1775 Aurora Ct.
Aurora, CO 80045
Website
303-724-2323 (Phone)
303-724-6779 (Fax)

Job Titles
Academic - Professor
Division Academic - Head, Division of Rheumatology
Division Academic - Smyth Professor of Rheumatology

Department, Section / Division
Medicine, Medicine-Rheumatology

Recognition & Awards
American Asthma Foundation, Senior Fellow (2010)

Professional Memberships
American Rheumatology Research and Education Foundation - Chair, Scientific Advisory Council
American College of Rheumatology - Abstract Selection Subcommittees
American College of Rheumatology Research and Education Foundation - Member, Board of Directors
Research & Grants
Research Interests
Dr. Holers is performing basic and translational research on the roles of complement receptors and membrane regulatory proteins in the immune response, with a special emphasis on B lymphocytes and autoimmune diseases. Complement is a complex system of serum proteins which, upon activation, covalently bind targets (bacteria, viruses, immune complexes) and marks them as foreign. The interaction of complement with B cell receptors also results in substantial enhancement of humoral and cellular immunity. In addition to this role, excessive activation of complement is centrally involved in autoimmunity and the tissue damage that occurs in many inflammatory diseases involving organs such as the kidney. The Holers’ laboratory has developed human and mouse models in which to study these complement related biologic processes and develop inhibitors. With regard to the natural history studies of RA, we now know that autoimmune diseases begin years before clinical signs and symptoms are apparent, when at-risk individuals manifest highly predictive autoantibodies in their serum. This observation suggests that additional therapeutic and/or prevention strategies could be considered for individuals in this at-risk but asymptomatic period. It is also relevant to determine how individuals transition from this autoantibody-positive, at-risk period to clinically active disease, and ongoing studies have been started that are related to understanding these questions.
Information for Referring Providers
Clinical Interests for Referring Providers: I am interested in Complement and SLE, RA Pathogenesis.

Research Interest for Referring Providers: Dr. Holers is performing basic and translational research on the roles of complement receptors and membrane regulatory proteins in the immune response, with a special emphasis on B lymphocytes and autoimmune diseases. Complement is a complex system of serum proteins which, upon activation, covalently bind targets (bacteria, viruses, immune complexes) and marks them as foreign. The interaction of complement with B cell receptors also results in substantial enhancement of humoral and cellular immunity. In addition to this role, excessive activation of complement is centrally involved in autoimmunity and the tissue damage that occurs in many inflammatory diseases involving organs such as the kidney. The Holers’ laboratory has developed human and mouse models in which to study these complement related biologic processes and develop inhibitors. With regard to the natural history studies of RA, we now know that autoimmune diseases begin years before clinical signs and symptoms are apparent, when at-risk individuals manifest highly predictive autoantibodies in their serum. This observation suggests that additional therapeutic and/or prevention strategies could be considered for individuals in this at-risk but asymptomatic period. It is also relevant to determine how individuals transition from this autoantibody-positive, at-risk period to clinically active disease, and ongoing studies have been started that are related to understanding these questions.

Hospital Affiliation
University of Colorado Hospital

Clinical Location: Aurora - Barbara Davis Center for Childhood Diabetes - Specialty Clinic

Clinic Phone: 720-848-1940
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