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Grants

Advancing Treatment for Pediatric Craniopharyngioma: Biologically Guided Medical Therapy (2013)

A randomized controlled trial of anterior versus posterior entry site for cerebrospinal fluid shunt insertion (Site PI) (2015)

Advancing Treatment for Pediatric Craniopharyngioma (ATPC): Preliminary Assessment of the Cyst Fluid Inflammatory Milieu (2016)

Posterior Fossa Decompression with or without Duraplasty for Chiari Type I Malformation with Syringomyelia. (Site PI) (2016)

Pilot Study of IL-6 Mediated Inflammation in the Cystic Component of Adamantinomatous Craniopharyngioma. (2016)

Verification of Therapeutic Targets and Assessment of Tumor Heterogeneity using Microdissection and Next Generation Sequencing in Adamantinomatous Craniopharyngioma. (2016)

Pre-Clinical Trial of Anti-Inflammatory Monoclonal Antibodies in a Mouse Model of Adamantinomatous Craniopharyngioma. (2017)

Comparison of Adult Adamantinomatous Craniopharyngioma Gene Expression with Known Pediatric Gene Expression (2017)

Decision Making about Intracranial Pressure Monitoring in Children with Traumatic Brain Injury (2017)

Identifying Directed Therapies for Adamantinomatous Craniopharyngioma using Advanced Biological Techniques and Genetically Engineered Mouse Models (2018)

Endoscopic Versus Shunt Treatment of Hydrocephalus in Infants (ESTHI) (2019)

Creation of a Single Cell Atlas of Pediatric Brain Tumors (2019)

Advancing Treatment for Pediatric Craniopharyngioma (ATPC): in vivo Tocilizumab Measurement (2019)

Deep Learning Methods to Concurrently Interrogate Multiple Instances of Clinical Images to Enhance Patient Care (2019)

Predictive Diagnosis and Genomics of Pediatric Neurosurgical Tumors via Convolutional Neural Networks (2019)

Innovation Award. Deep Learning Methods to Concurrently Interrogate Multiple Instances of Clinical Images to Enhance Patient Care (2019)

Developing a Clinically Translatable Interpretable 3D Radiographic and Transcriptomic Joint Domain Deep Learning Framework for Limited Datasets Using Adamantinomatous Craniopharyngioma as an Example (2020)

Characterization of Epithelial-to-Mesenchymal Transition in Adamantinomatous Craniopharyngioma (2020)

Intelligent System Design for Interpretable Deep Learning Modeling of Rare Pediatric Brain Tumors from a Multi-disciplinary Perspective (2021)

Biological Response to Novel Treatments in Adamantinomatous Craniopharyngioma and Exploratory Profiling of Cystic Fluid (2021)

Advancing Characterization of Epithelial-to-Mesenchymal Transition in ACP through Phospo-kinase Analysis (2021)

Preclinical testing of the Immunotherapeutics Nivolumab, Bevacizumab and Adecatumumab using ex vivo Adamantinomatous Craniopharyngioma Tissue (2021)

Complement Activation in Cerebrospinal Fluid of Neonatal Intraventricular Hemorrhage Patients Predicts Post-Hemorrhagic Hydrocephalus. (2022)

Development of a public web-based tool to refine interpretable AI tools in pediatric neuro-oncology (2022)

Complement Activation in Cerebrospinal Fluid of Neonatal Intraventricular Hemorrhage Patients Predicts Post-Hemorrhagic Hydrocephalus. (2022)

Preclinical testing of the small molecule inhibitors Navitoclax, and Binimetinib using ex vivo Adamantinomatous Craniopharyngioma Tissue (2022)

Demonstrate the Impact of MMP-9 Knockdown in 3 Novel ACP Models (2022)

Multiplex Immunofluorescence spatial distribution in ACP (2022)

Research Interests for Patients

My research interests focus in 3 areas: 1. Pediatric Brain Tumors - I assembled and lead the only multi center consortium in North America that focuses on the improvement of therapies for pediatric craniopharyngioma: Advancing Treatment for Pediatric Craniopharyngioma. We use tissue and clinical data to study gene expression and correlate this with potential available medical therapies. Further information regarding our consortium can be found at: https://www.childrenscolorado.org/pediatric-innovation/research/neuroscience/atpc-consortium/ 2. Hydrocephalus - I am the Children's Hospital Colorado site principal investigator for the Hydrocephalus Clinical Research Network. This is a multicenter consortium that completes clinical outcomes research aimed at improving treatment for children with hydrocephalus: http://www.hcrn.org 3. Pediatric cervical spine disease. I am a member of the Pediatric Craniocervical Society, which is a small group of pediatric neurosurgeon who conduct research aimed at improving therapies for children with diseased of the cervical spine and occipitocervical region.