Research & Grants
Grants
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Stress and Human Stem/Progenitor Cells: Biobehavioral Mechanisms (2022)
NIH/NICHD R01, $3300212
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Biological Embedding of Social Disadvantage in Human Stem Cells: Implications for Health Disparities (2022)
NIH/NIMHD, $3092798
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Impact of weight loss on the intrinsic circadian clock in human skeletal muscle (2021)
The Colorado Clinical & Translational Sciences Institute, $60000
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Umbilical cord-derived stem cell metabolism: Understanding mechanisms for childhood obesity risk (2018)
The American Diabetes Association, $600000
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Epigenetic programming of infant mesenchymal stem cells: mechanisms for obesity and diabetes risk in humans (2018)
NIH/NIDDK R01, $1677000
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Human Mesenchymal Stem Cells and the Epigenetic Programming of Obesity (2015)
NIH/NIDDK K01, $397000
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Mesenchymal Stem Cells and the Epigenetic Programming of Neonatal Adiposity (2014)
The Colorado Clinical & Translational Sciences Institute , $1000
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Mesenchymal Stem Cells and the Epigenetic Programming of Neonatal Adiposity (2014)
University of Colorado Center for Women’s Health Research, $25000
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The Effect of Maternal Obesity on Skeletal Muscle Cell Differentiation (2013)
The Obesity Society, $25000
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Maternal Programming of Fetal Stem Cells (2013)
NIH/NICHD K12 BIRCWH, $
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Cellular Mechanisms for Insulin Resistance in Human Gestational Diabetes Mellitus (2011)
NIH/NIDDK F32, $
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Postdoctoral Fellow (2009)
NIH/NIDDK T32 DK 007658, $
Research interests for Patients:
I have a robust foundation in obesity research, with 18 years dedicated to identifying and understanding metabolic phenotypes in primary human stem cells. My research program aims to understand how fetal exposures predispose infants to metabolic disease later in life. In pursuit of this goal, my lab pioneered the use of mesenchymal stem cells collected from umbilical cord tissue of newborn infants to investigate molecular and metabolic phenotypes predictive of future disease risk. Such tools have allowed us to identify children most at risk for excess adiposity in childhood with greater precision than other common measures collected at birth. As we move toward precision approaches for obesity prevention, infant stem cells will help to identify gestational exposures most impactful, and their modifiability through pregnancy interventions, thereby informing evidence-based prenatal clinical care.