Wells Messersmith, MD
Professor, Medicine-Medical Oncology

Division Head
Associate Director for Translational Research
Featured Provider Photo

Gender: Male
Languages: English
Department, Section/Division: Medicine-Medical Oncology

Practice Locations

UCH - Cancer Center
1665 Aurora Ct
Aurora, CO 80045
720-848-0300
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CU Specialty Care at Highlands Ranch Cancer Care - Medical Oncology
1500 Park Central Drive, Suite 101
Highlands Ranch, CO 80129
720-516-1100
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University of Colorado Hospital (UCH)
12605 E. 16th Ave
Aurora, CO 80045
720-848-0000
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UCH - Anschutz Outpatient Pavilion
1635 Aurora Ct
Aurora, CO 80045
720-848-0000
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UCHealth - Lone Tree Health Center
9548 Park Meadows Drive
Lone Tree, CO 80124
720-848-2200
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Hospital Affiliation
  • University of Colorado Hospital
  • UCHealth Highlands Ranch Hospital
Center Affiliations

Specialty Information

Specialties
  • Internal Medicine, Board Certification (2001)
  • Internal Medicine - Medical Oncology, Board Certification (2003)
Conditions & Treatments
  • Cancers
  • Anal Cancer
  • Colorectal Cancer
  • Gastroenterologic Cancer (Colon, Stomach, Esophageal, Liver)
  • Pancreatic Cancer
  • Digestive System
  • Gastroenterology (Stomach, Bowel, General GI Problems)
Clinical Interest for Patients
I am interested in Gastrointestinal Cancers (Colorectal, Pancreatic, Gastric, Esophageal, Hepatocellular, Gallbladder, Bile Ducts, Anal, GI, Stromal Tumors, Abdominal Carcinoma of Unknown Primary), Drug Development (Experimental Therapeutics) and Translational Research.

Care Philosophy
We strive to provide patient-focused, personalized, multi-disciplinary care for gastrointestinal (GI) cancers. Our specialized providers in Medical Oncology (chemotherapy and targeted therapies), Surgical Oncology, Radiation Oncology, Pathology, Molecular Pathology, Radiology, Interventional Radiology, Nuclear Medicine, Gastroenterology (both Hepatology and Interventional Endoscopy), Nutrition, and Integrative Medicine work together to achieve the best outcomes for our patients. We have weekly GI cancer tumor boards, where our specialists come together to discuss patients and patient care.

Volunteer Activities
I have given GI cancer lectures at national meetings (ASCO, AACR) and at community cancer centers across the US and Europe. I also participate in grant, abstract, and manuscript reviews in my field.

Information for Referring Providers

Clinical Interests for Referring Providers
Gastrointestinal Cancers (Colorectal, Pancreatic, Gastric, Esophageal, Hepatocellular, Gallbladder, Bile Ducts, Anal, GI, Stromal Tumors, Abdominal Carcinoma of Unknown Primary), Drug Development (Experimental Therapeutics), Translational Research

Research Interest for Referring Providers
My lab is mainly focused on using a personalized approach in developing new anticancer drugs for GI cancers. In particular, the lab uses a novel colorectal and pancreatic explant model whereby tumor tissue is obtained from the operating room and then placed directly into mice. Tumors are treated with new drugs and predictive biomarkers of sensitivity are discovered. These predictive markers are used in the clinic to pre-select patients that would most likely derive benefit from these new drugs. Additionally, these tumors are evaluated in orthotopic and metastatic models. Current anticancer drugs in the lab target Notch (g-secretase), Src, and hedgehog pathways.
Clinic Phone: (720) 848-0300
Fax Phone: (303) 724-3892
Lab Phone: (303) 724-3808